What is it about?
The study aims to understand why lung cancer cells are resistant to TRAIL. GSK3β increases c-FLIP in these cells, which prevents TRAIL from working. The team investigated whether ITCH regulates c-FLIP through GSK3β during TRAIL therapy. Results showed that GSK3β regulates c-FLIP stability via ITCH and affects cell death induced by TRAIL in lung cancer cells.
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This page is a summary of: GSK3β/ITCH/c-FLIP Axis Counteracts TRAIL-induced Apoptosis in
Human Lung Adenocarcinoma Cells, Protein and Peptide Letters, March 2023, Bentham Science Publishers,
DOI: 10.2174/0929866530666230112165515.
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