What is it about?
Oxidative stress constitutes an important risk factor for tissue/cell damage and is involved in the occurrence and progression of osteoarthritis (OA). The aim of this study was to evaluate the concentration of malondialdehyde (MDA) in synovial fluid (SF) and blood as well as the activity of serum and SF paraoxonase (PON1) of patients with OA. Our study aimed to assess local and systemic responses to oxidative stress.
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Why is it important?
The changes observed in osteoarthritic SF show that the process of antioxidant enzymatic defence is intensified locally, not systemically. The lipid hydroperoxides elimination may lead to restore joints homeostasis. Based on natural history and intraoperative findings it is well observed that hip OA develops with smaller synovial reaction than knee OA. This fact may explain the differences between PON activity in either joint OA in our study and also confirms more severe impact of disease on the knee joint. The changes observed show that, the osteoarthritic SF antioxidant enzymatic defense seeks to lipid hydroperoxides elimination, aiming to restore joints homeostasis.
Perspectives
Further investigations with a larger group, more data on diet (as PON1 activity depends on this habit) and also knowledge about the values of determined parameters in the normal joint fluid are necessary before stating more univocal conclusions. The changes observed show that, the osteoarthritic SF antioxidant enzymatic defense seeks to lipid hydroperoxides elimination, aiming to restore joints homeostasis.
PhD, Assoc. Prof. Dorota M Olszewska-Słonina
Read the Original
This page is a summary of: Evaluation of Selected Parameters of Lipid Peroxidation and Paraoxonase Activity in Blood of Patients with Joint Osteoarthritis, Protein and Peptide Letters, November 2018, Bentham Science Publishers,
DOI: 10.2174/0929866525666180821120050.
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