What is it about?
Acyltransferases (ATs) transfer acyl units into acyl carrier proteins (ACPs) via a self-acylation reaction and a transacylation reaction. Here we used AT10FkbA of FK506 biosynthetic polyketide synthase (PKS) from Streptomyces tsukubaensis YN06 as a model to study the specificity of ATs for acyl units.
Featured Image
Why is it important?
Many polyketide natural products have been used as medicines or biological active agents. Acyltransferases play an essential role in the polyketide biosynthesis.
Perspectives
This paper expanded our understanding of acyltransferases.
Dr Hui Jiang
Zhejiang University
Read the Original
This page is a summary of: Biochemical Characterization of a Malonyl-Specific Acyltransferase Domain of FK506 Biosynthetic Polyketide Synthase, Protein and Peptide Letters, November 2014, Bentham Science Publishers,
DOI: 10.2174/0929866521666140926113322.
You can read the full text:
Contributors
The following have contributed to this page
