What is it about?
Hand foot syndrome is one of the ADR (adverse Drug Reaction) due to Lenvatinib. The identification and timely diagnosis of HFS (Hand Foot Syndrome) is important as the dose modification or discontinuation of the drug will revert the condition. Lenvatinib is an oral formulation which the patients can take at their homes. Hence educating the patients regarding the HFS is important so that they report it to the treating physicians on time. This will help the physicians for the early discontinuation and appropriate treatment with corticosteroids which will help in improving the quality of life of the patients who are already suffering from cancer.
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Why is it important?
The treatment for HFS (Hand Foot Syndrome) is withdrawal of culprit drug followed by oral corticosteroids. In our case, Lenvatinib (prescribed for Pulmonary metastases of Endometrial carcinoma) was withheld and the patient was treated with oral prednisolone. The lesions disappeared and the patient felt better after five days of oral prednisolone.
Perspectives
I would like to express my gratitude to all the co-authors (mentors) for their invaluable guidance and recommendations. This case report highlights hand Foot syndrome as an adverse drug reaction caused by Lenvatinib and that the monitoring and precautionary measures should be taken to prevent HFS.
Kiran Rangshahi
All India Institute of Medical Sciences
Read the Original
This page is a summary of: Hand Foot Syndrome Induced by Lenvatinib - A Case Report, Current Drug Safety, May 2025, Bentham Science Publishers,
DOI: 10.2174/0115748863281030240304105117.
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