What is it about?
Based on the current antimicrobial activities reported for cinnamic derivatives as well as the synthetic versatility of N-aryl-2-chloroacetamides, we designed twelve non-toxic cinnamic amidoesters on Artemia salina to study the effects of aromatic substituents on the activity against Escherichia coli, which causes a neglected tropical disease, Staphylococcus aureus, the most dangerous bacterium among staphylococcal bacteria, and Mycobacterium tuberculosis, an urgent public health issue due to resistance.
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Why is it important?
The best results were obtained against S. aureus for unsubstituted and para-substituted compounds (R3 = H, Me, Cl, Br), whose molecular docking study demonstrated affinity with the TtRNA enzyme, suggesting that the mechanism of antibacterial action may be the inhibition of this enzyme.
Perspectives
This article was a turning point, through which we resumed consistent research in our laboratory.
Gabriela Fiss
Universidade Federal da Paraiba
Read the Original
This page is a summary of: In silico/vitro Study of Antibacterial Effects of Non-toxic Cinnamic Amidoesters on
Artemia salina, Current Organic Chemistry, September 2025, Bentham Science Publishers,
DOI: 10.2174/0113852728310711240525123954.
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