Co-loading Radio-photosensitizer Agents on Polymer and Lipid-based Nanocarriers for Radio-photodynamic Therapy Purposes: Review

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Why is it important?

This study shows how polymer- and lipid-based nanocarriers can improve cancer treatment by co-delivering radiosensitizers and photosensitizers for combined radiotherapy and photodynamic therapy (RT–PDT). It discusses how these nanocarriers can encapsulate hydrophilic and hydrophobic agents, potentially improving drug delivery, combining therapeutic effects, and enhancing cancer-cell destruction. The review also examines different polymeric systems, particularly PLGA nanoparticles, the underlying biophysical mechanisms, and the advantages and challenges of co-delivery. Overall, the article highlights the potential of nanotechnology to develop more effective integrated cancer therapies while identifying key barriers to clinical translation.