What is it about?
We analyzed mitochondria from patient's cells affected by either acute lymphoblastic (ALL) or myeloid (AML) leukemia. We sequenced the D-loop of the mitochondrial genome, a region that was previously demonstrated to be altered in cancer. Such modifications, could in turn participate to cancerogenesis.
Featured Image
Why is it important?
Our data are in contradiction with other studies previously reporting somatic mitochondrial DNA mutation. However, we found that in such patient's cells, the mtDNA level and the production of reactive oxygen species were significantly increased compared to healthy subjects.
Perspectives
The increase in mtDNA level could participate in leukemogenesis by stimulating the ATP production by the respiratory chain. Such hypothesis should be evaluated.
stephane allouche
Universite de Caen Normandie
Read the Original
This page is a summary of: Mitochondrial DNA Alterations and Oxidative Stress in Acute Leukemia, The Open Leukemia Journal, May 2013, Bentham Science Publishers,
DOI: 10.2174/1876816420130418001.
You can read the full text:
Resources
Contributors
The following have contributed to this page
