The Nephroprotective Effect of N-Acetyl-L-Cysteine and Atorvastatin against Imipenem induced Nephrotoxicity.

Abeer M. Rababa`h , Tamara B. Hijjawi, Karem H. Alzoubi, Saddam Al Demour , Mera A. Ababneh
  • Current Molecular Pharmacology, July 2017, Bentham Science Publishers
  • DOI: 10.2174/1874467210666170731115928

Nephroprotective and Nephrotoxicity N-Acetyl-L-Cysteine and Atorvastatin Imipenem Nephrotoxicity

What is it about?

A research on rats to show the effect of pre-administration of either NAC or atorvastatin to protect the kidneys from imipenem-induced nephrotoxicity, through their antioxidant effects.

Why is it important?

Imipenem has played an important role in the treatment of broad-spectrum bacterial infection. However, nephrotoxicity due to imipenem remains an important clinical challenge. The study test the hypothesis stating that N-acetyl-L-cysteine (NAC) and atorvastatin possess a nephroprotective effect against imipenem-induced nephrotoxicity and show that pre-administration of either NAC or atorvastatin protects the kidneys from imipenem-induced nephrotoxicity, through their antioxidant effects.

The following have contributed to this page: Abeer Rababah and Dr Tamara Bassam Hijjawi