What is it about?
Although numerous articles have highlighted the role of gut microbiota and its effect on Central Nervous System (CNS) physiology and neurochemistry, the present review solely focuses on the ability of externally administered probiotic strains (that may or may not be part of the already existing gut microflora of an average human) in ameliorating the altered CNS functions in patients. The review aims at giving a comprehensive analysis of the studies performed on animals and humans and discusses the findings in different neurological and psychiatric disorders (Anxiety, Major Depressive disorder, bipolar disorder, schizophrenia, autism spectrum disorder, cognitive impairments etc). The article also highlights different mechanisms through which the probiotic bacteria operate in improving neurologic manifestations or decreasing the incidence of neurological disorders. These underlying mechanisms include both direct as well as indirect pathways involving neural, hormonal and immunological pathways.
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Why is it important?
There has been a significant rise in the occurrence of various neurological ailments worldwide. The need to investigate newer and safer intervention therapies is very much needed. Probiotics have recently been shown to hold promise as an intervention option that warrants future work. Probiotic strains have shown beneficial treatment outcomes as evidenced in various animal and human studies. Our study emphasizes on the regular intake of probiotic and probiotic based foods to be used as an as an important dietary modification as well as a useful intervention therapy for the target population suffering from neurological and psychiatric disorders (Anxiety, Major Depressive disorder, bipolar disorder, schizophrenia, autism spectrum disorder, cognitive impairments etc).
Perspectives
People shy away to talk about mental ailments and sadly, in the present era of competition and stress, there has been a significant rise in the incidence of neurological and psychiatric ailments especially depression , bipolar, acute anxiety and panic attacks being very common. Many of these conditions are actually never talked about openly causing the worsening of the conditions in absence of proper treatment.This article stresses and focuses on the regular use and intake of probiotics and prebiotic diet that have been proved to hold prophylactic potential in preventing the onset or at least decreasing the severity of associated symptoms in patients of many such neurological disorders. I am sure this article will give you an insight into the role of probiotics and will be though provoking and of utility to the community at large.
Dr. Sandeep Kaur
Read the Original
This page is a summary of: The Effect of Probiotic Intervention in Ameliorating the Altered Central Nervous System Functions in Neurological Disorders: A Review, The Open Microbiology Journal, February 2020, Bentham Science Publishers,
DOI: 10.2174/1874285802014010018.
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