What is it about?

Pseudomonas(p.) aeruginosa is one of the leading reasons for nosocomial infections. The pathogenicity of P. aeruginosa is related to its inherent antimicrobial resistance and the diverse virulence factors of this bacterium. Owing to the specific role of exotoxin A in P. aeruginosa pathogenesis, it is known as a promising therapeutic candidate to develop antibodies as an alternative for antibiotics.

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Why is it important?

In summary, a recombinant human scFv which is neutralizing exotoxin P. aeruginosa recommended as a promising treatment of infections caused by P. aeruginosa.


In my perspective,data from computational biology could provide protein-protein interaction information between scFv antibody/domain I exotoxin A and offers new insights into antibody development and therapeutic expansion.

Zahra Shadman

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This page is a summary of: In silico Validation of Pseudomonas aeruginosa Exotoxin A Domain I Interaction with the Novel Human scFv Antibody, Infectious Disorders - Drug Targets, August 2023, Bentham Science Publishers,
DOI: 10.2174/1871526523666230329104537.
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