Isolation and Quantitative Methods for Analysis of Non-Steroidal Anti-Inflammatory Drugs

  • Ana I. Olives, Victor Gonzalez-Ruiz, M. Antonia Martin
  • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, September 2012, Bentham Science Publishers
  • DOI: 10.2174/187152312803476273

What is it about?

This Perspectives article covers the most relevant current strategies aimed at reducing the environmental fingerprint caused by mobile phases in liquid chromatography. Modern stationary phases, such as columns packed with core− shell particles or stationary phases allowing high-temperature separations, are discussed. Mobile-phase additives creating secondary partitioning equilibria (micelle-forming reagents, cyclodextrins, or ionic liquids) and alternatives to acetonitrile as organic solvent are critically compared in terms of separation efficacy and wastes’ toxicity. Advantages of CO2 and superheated solvents are also considered to complete the picture of the most recent developments in the field.

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The following have contributed to this page: M. Antonia Martín