What is it about?

The current use of antineoplastic drugs in human therapy causes a substancial number of toxic or side effects which consequently lead to a reduction of the amount of drug to be administered, and in some cases to discontinuation of the therapy. A reduction of the amount of drug to be administered or discontinuation of the therapy causes an increase in primary tumour growth and/or the occurrence of tumour metastases. For this reason, the development of new anti-cancer drugs with lower side effects is necessary. This review gives a general idea about the origins of cancer and the importance of cyclooxygenase-2 (COX-2) in oncogenesis. Evidence from clinical and preclinical studies indicates that COX-2–derived prostaglandins participate in carcinogenesis, inflammation, immune response suppression, apoptosis inhibition, angiogenesis, and tumour cell invasion and metastasis. The recent anti-tumour drugs are based on tests of known selective COX-2 inhibitors and on the drawing and synthesis of new potent derivatives. Maybe, this can be the way to obtain new anti-tumour drugs with very low collateral effects. Selective COX-2 inhibitors are being mixtured with new anti-cancer drugs in order to obtain better results in the regression of cancers. Some natural products are selective COX-2 inhibitors and have anti-inflammatory and anti-cancer properties. The relevant patents are discussed.

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Why is it important?

Using commercially available anti-inflammatory drugs such as celecoxib, rofecoxib, indomethacin and resveratrol to regress, cure and prevent cancer is an interesting alternative.

Perspectives

I believe that human trials of rofecoxib to regress and cure cancer can be done. It is an interesting alternative as a co-adjuvant treatment.

Ricardo de Souza Pereira
Universidade Federal do Amapa

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This page is a summary of: Selective Cyclooxygenase-2 (COX-2) Inhibitors Used for Preventing or Regressing Cancer, Recent Patents on Anti-Cancer Drug Discovery, June 2009, Bentham Science Publishers, DOI: 10.2174/157489209788452849.
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