What is it about?

The current review analyzed the association of leptin receptor polymorphisms as an etiology for PCOS and included studies that looked at other putative leptin interactions that could lead to PCOS such as, its association with female reproductive hormones, obesity, and insulin resistance

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Why is it important?

Leptin and leptin receptors may directly or indirectly affect the onset of PCOS in women. Genetic factors should also be considered while correlating leptin and its receptor with PCOS.


This article highlighted one of the rare, novel, and possible genetic factors in one of the emerging conditions, polycystic ovarian syndrome. I hope this review encourages looking at Leptin from a different perspective and further investigations to be planned based on this review.

Srujana Medithi

Read the Original

This page is a summary of: Prospective Role of Leptin Receptor Gene and its Polymorphisms on the Onset of Polycystic Ovarian Syndrome, Current Women s Health Reviews, May 2023, Bentham Science Publishers,
DOI: 10.2174/1573404820666230330104046.
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