What is it about?
Synthesis of aminoalkyl iodides from the corresponding aminols were demonstrated under sonication reaction with diphosphorus tetraiodide (P2I4) in CS2. Further, the utilization of the alkyl iodides to aminoalkyl thiols was established. The latter compounds serve as building blocks for many heterocycles and other drug candidates. The ultrasonication medium works effectively for all the intermediates preparation; the conditions are mild, and yields are almost quantitative in all steps.
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Why is it important?
Milder reaction conditions Simple P2I4 reagent Sonication for the reaction Diverse applications
Perspectives
This publication serves the chemists to find the alternative and easy route for the incorporation of iodo group at the -COOH terminus under simple conditions and thus can be converted to various other functional groups for the multistep organic synthesis.
Dr. Nagendra G
Read the Original
This page is a summary of: Ultrasound-accelerated Synthesis of N-protected Amino Alkyl Iodides
from Amino Alcohols Using P2I4 Reagent and its Application in the
Synthesis of Amino Alkyl Thiols, Letters in Organic Chemistry, March 2024, Bentham Science Publishers,
DOI: 10.2174/1570178620666230913160751.
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