What is it about?

One of the main stressor at high altitudes is hypoxia. Metabolic responses to hypoxia play important roles in cell survival strategies and some diseases. Tibetans and yaks are two perfect examples innate to the plateau for high altitude adaptation. Gene-expression can be changed by a variety of signals originating from the environment, and hypoxia is the main factor amongst them. The hypoxia-inducible factors (HIF-1α and EPAS1/HIF-2α) are the main regulators of oxygen in homeostasis, which play a role as maestro regulators of adaptation in the hypoxic reaction of molecular mechanisms.

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Why is it important?

The world's highest and largest altitude area is called the Qinghai-Tibetan plateau QTP, which harbors unique animal and plant species. Mammals that inhabit the higher altitude regions have adapted well to the hypoxic conditions. One of the main stressor at high altitudes is hypoxia. Metabolic responses to hypoxia play important roles in cell survival strategies and some diseases. However, the homeostatic alterations that equilibrate variations in the demand and supply of energy to maintain organismal function in a prolonged low O2 environment persist partly in understood, making it problematic to differentiate adaptive from maladaptive responses in hypoxia.

Perspectives

The topic of this article is very important and interesting. Hypoxia is the main irritant of cellular injury as lack of oxygen may cause many problems. ATPs are main source of energy on cellular level, their production needs oxygen. If there is lack in supply of oxygen on a constant basis cell go under adaptation.

Asma Babar
Lasbela University of Agriculture Water and Marine Sciences

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This page is a summary of: High Altitude Hypoxia, Current Proteomics, October 2021, Bentham Science Publishers, DOI: 10.2174/1570164617999201002144747.
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