What is it about?
It is about studies of Impurity profile of several drugs used in asthma. There are 3 types of impurities (organic, inorganic, residual solvents) other than drug substance. Identification of impurities is done by various instrumental methods like Chromatography (HPLC, HPTLC, GC), Spectroscopy (MS, NMR, FTIR, UV) & combination of both (LC-MS/MS, GC-MS/MS). It is also included tables to show various toxicity studies of various impurities.
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Why is it important?
It is important to characterize the impurities like LC-MS/MS, GC-MS/MS to know the exact mass of respective impurities & after that isolate that impurities from the mixture like by preparative HPLC, column chromatography, flash chromatography etc. Moreover toxicity studies of impurities is important to know the toxicity & harmful effect of impurities present in drug.
Perspectives
I hope this article gives various useful information in health sector. Various list of drugs used in asthma is included with their impurities as well as toxicity studies of impurities. It is basically aware the people regarding drugs they taken contain impurities & some impurities is also toxic & produce several harmful effects.
KRUNAL PRAJAPATI
Nirma University of Science and Technology
Read the Original
This page is a summary of: Impurity Profile of Bronchodilators used in Asthma: A Critical Review, Current Drug Discovery Technologies, September 2018, Bentham Science Publishers,
DOI: 10.2174/1570163814666170829141614.
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