What is it about?

We review the neuroprotective role of C-terminus of HSP70 Interacting Protein (CHIP) in neurodegenerative diseases including Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, Huntington disease, and other polyglutamine expansion diseases. In addition, we summarize the literature to date on neurodegenerative cerebellar ataxias caused by mutations in the gene encoding CHIP.

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Why is it important?

CHIP has been demonstrated to play a protective role in many neurodegenerative diseases and could be a promising target for the development of novel therapeutics but has yet to receive widespread attention. Further, several people with CHIP-associated cerebellar ataxia have been described in the literature, but this information had yet to be consolidated.


We hope that this review will increase awareness of CHIP and CHIP-associated diseases, as well as promote further investigation into CHIP and neurodegeneration.

Lorraine Kalia
University of Toronto

Read the Original

This page is a summary of: C-terminus of Hsp70 Interacting Protein (CHIP) and Neurodegeneration: Lessons from the Bench and Bedside, Current Neuropharmacology, June 2021, Bentham Science Publishers,
DOI: 10.2174/1570159x18666201116145507.
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