What is it about?

A new design of topical buccal bilayer mucoadhesive, thin and flexible film contains sodium alginate and gellan gum loaded with low dose of 1 mg prednisolone sodium phosphate. In vivo study in rabbits showed that this film was able to promote aphthous ulcer healing with shorter treatment duration.

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Why is it important?

The current marketed prednisolone sodium phosphate products for anti-inflammatory use are mainly oral, ophthalmic and parenteral preparations. Oral tablets dose should be given 5 to 60 mg per day in divided doses 1 to 4 times/day. However, when corticosteroids are regularly used long-term, the possibility of increased numbers of oral yeast infections and other side effects are very common. We developed a new type of buccal bilayer mucoadhesive film loaded with prednisolone in a dose equivalent to only one fifth of the oral dose.

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This page is a summary of: Promote Recurrent Aphthous Ulcer Healing with Low Dose Prednisolone Bilayer Mucoadhesive Buccal Film, Current Drug Delivery, January 2017, Bentham Science Publishers, DOI: 10.2174/1567201813666160316122548.
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