Exploration of Potential Mechanisms of LQHBG for Treating DR Based on Network Pharmacology.

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DR is characterized by structural and functional changes that are affected by multiple factors. The current clinical studies identified new targets for the treatment of DR and confirmed that the traditional Chinese medicine components acting on these potential targets play important roles in the prevention and treatment of DR. In this study, the bioactive components and targets of the LQHBG in treating DR were analyzed and predicted through a network pharmacology method, while the mechanisms of action of key genes and pathways were analyzed through bioinformatics methods. It can be seen from the network diagram of bioactive components–targets and pathway analysis that quercetin is most the common component of the four single drugs in the LQHBG, which act together on the core gene of ALB, reflecting the synergistic effects of compound Chinese medicine components. Each herb consists of different bioactive ingredients, acting on diverse drug targets, referred to as the AGE-RAGE, HIF-1a, PI3K Akt, MAPK, and NF-kappa B signaling pathways, treating DR from different therapeutic aspects of the circulation, metabolism, inflammation, and aging, embodying the complementary effects of compound Chinese medicine in the treatment of DR with multiple components, multiple targets and multiple approaches, providing a new idea for the treatment of DR with complex pathogenesis. Because the results of this study were only obtained from available databases and the obtained pathways were relatively wide, failing to fully elucidate the molecular regulation and interaction relationships, the next step will be undertaking in vitro experiments and performing analysis of the biological technology, further verifying the accuracy of the targets of the Chinese herbal compound LQHBG and will be focusing on each single pathway to study the molecular regulation and interaction relationships, further exploring the specific mechanisms of action of this Chinese herbal compound in treating DR.

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