What is it about?
We evaluated a number of research articles in this study that reported efficient, less hazardous and convenient catalytic operations for the synthesis of novel fluorinated heterocyclic compounds, moderate to good in yield. Some fluorinated methods are classic, but they have been modified in new version to produce key building blocks in an easy process, allowing the downstream construction of more complex bioactive products being achieved in a short period of time.
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Why is it important?
This review offers the advantage of modified methods of synthesis of multicomponent fluorinated compounds. In addition, the review highlights the literature illustration of the fluorine atom replacements with other atoms like hydrogen, etc. The study demonstrates the significance of fluorinated compounds in the construction of more complex molecules, which can be further used in many branches of chemical industry like dye, polymer, agrochemicals, medicines or drugs, etc.
Perspectives
This study also shows that because the fluorine atom is smaller in size, the strong intermolecular interactions and bond formation with other atoms affect the quality and quantity of the product formed. As fluorine atom gives conservative changes in the structure of natural products, making the product biologically more active and significant in the medicinal and agrochemical industry. The bond formation between fluorine and carbon in the molecules like CF2 increases the tolerance of the functional group in the complex molecules and hence the reactions are much efficient and simple to carry out. The fluorinated prodrug dexamethasone is currently high in demand for the treatment of COVID-19 virus all over the world. Henceforth, the aforementioned fluorine will be considered as interesting element to mislead the various virus mutations and cure more human diseases
Omkar Sharad Kamble
Institute of Chemical Technology
Read the Original
This page is a summary of: Recent Innovations of Organo-fluorine Synthesis and Pharmacokinetics, Current Organic Chemistry, November 2021, Bentham Science Publishers,
DOI: 10.2174/1385272825666210531111123.
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