What is it about?

CypD is localized in the mitochondrial transition pore, is a mitochondrial chaperone that has been shown to regulate mitochondrial function. This review focuses on the role of CypD in regulating mitochondrial function and provides a brief introduction to the relevant pathways as well as mechanisms, which provides new perspectives for related diseases.

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Why is it important?

We have conducted a literature review on mitochondrial diseases related to CypD, and we are also exploring the changes in mitochondrial function in drug-induced liver injury, delving into the role played by CypD, and providing a theoretical basis for drug-induced liver injury and mitochondrial related diseases.


I hope this article explains the relevant mechanisms of mitochondrial related diseases and the role of the target CypD in mitochondrial diseases. Our team is also committed to conducting relevant research and hopes to provide some insights for this purpose.

Shaoyun Zhou
China Pharmaceutical University

Read the Original

This page is a summary of: Cyclophilin D-mediated Mitochondrial Permeability Transition Regulates Mitochondrial Function, Current Pharmaceutical Design, March 2023, Bentham Science Publishers, DOI: 10.2174/1381612829666230313111314.
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