What is it about?
AKT1, ESR1, and EGFR have been identified as key molecular targets involved in Breast Cancer through roles in regulating cell growth, proliferation, and survival, ultimately contributing to cancer development. Citreorosein and Quercetin are polyphenols found in seagrass leaves have demonstrated potent anti-inflammatory activity, with citreorosein acting against tumor necrosis factor-alpha and quercetin showing inhibition of AKT1. For the first time, this study investigates the potential of citreorosein and quercetin to inhibit the activity of AKT1, EGFR, and ESR1.
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Why is it important?
Our finding shows that seagrass, an abundant marine weed, could be used as a source of molecules that can help in breast cancer management.
Perspectives
The work has immense potential as marine seagrasses are still under-studied and breast cancer needs new methods of management. Although, traditionally marine seagrasses are believed to have medicinal value, but it is not much explored in modern medicine.
Priyankar Sen
Vellore Institute of Technology, Vellore
Read the Original
This page is a summary of: Quercetin and Citreorosein from Halodule uninervis Leaf Show the Best Binding Against Breast Cancer Targets AKT1, EGFR, and ESR1, Current Pharmaceutical Design, March 2026, Bentham Science Publishers,
DOI: 10.2174/0113816128408970250717095140.
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