What is it about?
DAZ region is critical determinant region for non-obstructive azoospermia patients especially DAZ1/2 microdeletion.
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Why is it important?
the novelty is that spermatogenic impairment phenotype, present with AZFc microdeletions, is independent of the T54A variant in the DAZL gene, and AZFc microdeletions could be a causative agent in spermatogenic impairment.
Perspectives
In the future, our prospective will be around the differential functionality between DAZ1/2 and DAZ3/4 loci in NOA patients.
Alaaeldin Fayez
National Research Centre
Read the Original
This page is a summary of: Independent of DAZL-T54A variant and AZF microdeletion in a sample of Egyptian patients with idiopathic non-obstructed azoospermia, The Application of Clinical Genetics, July 2018, Dove Medical Press,
DOI: 10.2147/tacg.s158297.
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