The prognostic marker of ovarian cancer

What is it about?

In recent studies, PRDX1 was found to be abnormally expressed in esophageal 7, lung 8 and breast tumor cells, and was also found to be overexpressed in gynecological malignancies such as ovarian 10, endometrial 11 and cervical cancers 12. However, recent research has mainly focused on the roles of PRDX1 in the evaluation of clinical prognoses. In addition, literature regarding its functional mechanisms, especially its roles in malignant biologic behaviors of ovarian cancer cells, is scarce. In this paper, we investigated the mechanism of PRDX1 affecting the development and progression of ovarian cancer through experiments combined with bioinformatics.

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Why is it important?

we confirmed that PRDX1 is an independent risk factor for the prognosis of ovarian cancer. Down regulated the expression of PRDX1 can suppress ovarian cancer cell proliferation, invasion and metastasis. Pathways analysis of interaction network showed that tumor-related signaling pathways such as Wnt, FoxO, the cell cycle, and PI3K–Akt and MAPK pathways may be involved in . At present, various PRDX1-related studies of cancer exist, but we are the first to demonstrate that the inhibition of PRDX1 expression can suppress malignant biological behaviors such as proliferation, invasion and metastasis of ovarian cancer cells in ovarian cancer . In this study, bioinformatics analysis were innovatively combined to explore PRDX1-related mechanisms involved in the occurrence and development of ovarian cancer, thus providing a new direction for the further study of PRDX1.