EGFR mutation in squamous cell carcinoma Lung

What is it about?

EGFR mutations are uncommon in squamous carcinomas of lung and their clinical implication till date has been uncertain. This article emphasizes the value of testing EGFR in such tumours and their value in targeted therapy.

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Why is it important?

This is one of the largest series of EGFR mutation in squamous lung cancers. It's shows that these are not uncommon and rates are comparable to ALK positivity in adenocarcinomas. It is one of the few studies in this setting to show a improvement in survival with the use of tyrosine kinase inhibitors on multivariate analysis.