What is it about?
Serum VEGF level may be a good reflector of tumor burden.But studies about its predictive value in NSCLC showed inconsistant results.We performed our examination using Luminex multiplex assay to further identify its role as a predictive and prognostic biomarker for the efficacy of platinum-based chemotherapy in NSCLC.
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Why is it important?
We found that pretreatment serum VEGF levels may be a potential prognostic biomarker for the anti-tumor effcacy of platinum-based chemotherapy in terms of PFS. However, VEGF may not be a useful marker to anticipate the response to chemotherapy in patients with advanced NSCLC.
Perspectives
Serum VEGF is a very important marker for us to evaluate chemotherapy response and anticipate the prognosis of a patient.Further study may help us recognize its true significance.
Mrs Jialan Zang
Nanjing Medical University
Read the Original
This page is a summary of: Elevated serum levels of vascular endothelial growth factor predict a poor prognosis of platinum-based chemotherapy in non-small cell lung cancer, OncoTargets and Therapy, January 2017, Dove Medical Press,
DOI: 10.2147/ott.s124124.
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