What is it about?
About the impact that RRAD has on HCC and its mechanism
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Why is it important?
For further study and therapy about HCC
Perspectives
In this study, we have identified a novel functional recessive oncogene, RRAD, in HCC. Our findings indicate that RRAD regulates aerobic glycolysis and that metabolic reprogramming induced by RRAD inhibits cell proliferation and arrests HCC cells in G0/G1 in vitro. In vivo, overexpression of RRAD also retarded tumor growth. Moreover, cellular migration is impeded while apoptosis is promoted. These effects are consistent with a role for RRAD as a tumor suppressor in HCC.
Yingcai Yan
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This page is a summary of: Ras-related associated with diabetes gene acts as a suppressor and inhibits Warburg effect in hepatocellular carcinoma, OncoTargets and Therapy, June 2016, Dove Medical Press,
DOI: 10.2147/ott.s106703.
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