What is it about?
Cell membranes of neurons and glial cells are affected in ischemic stroke. Citicoline, also called a CDP-choline, is an intermediary in the biosynthesis of phosphatidylcholine - the structural phospholipid of cell membranes. In this review we summarize experimental and clinical data of neuroprotective and neuroregenerative role of citicoline in ischemic stroke.
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Why is it important?
Our review shows that in acute ischemic stroke citicoline has pleiotropic functions which include attenuation of glutamate exitotoxicity, oxidative stress, apoptosis, and blood-brain barrier dysfunction, and thus helps to protect and stabilize neuronal and glial membranes.
Read the Original
This page is a summary of: Current knowledge on the neuroprotective and neuroregenerative properties of citicoline in acute ischemic stroke, Journal of Experimental Pharmacology, October 2015, Dove Medical Press,
DOI: 10.2147/jep.s63544.
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