Insights into the pathogenesis of Langerhans cell histiocytosis

What is it about?

Tremendous sucess has been recently made in understanding the underlying mechanisms and the nature of Langerhans cell histiocytosis (LCH), a rare disease of the monocyte, macrophage and dendritic cell system. This paper summarizes new findings (e.g. gene mutations and affected cellular pathways) pertinent to disease biology , as well as their implications for monitoring of disease activity and targeted treatment of patients with LCH.

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