What is it about?
In this work, an attempt was made to decrease gastric ulceration laid by the non-steroidal anti-inflammatory drug, piroxicam. Piroxicam was incorporated into nano-sized particles, which, on ingestion, could've decreased contact between piroxicam and gastric mucosa and also decreased the rapid burst release of the drug in the stomach. The system showed good potential of amelioration of gastric ulceration.
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Why is it important?
The use of nanotechnology in drug delivery has long proved to be promising. And to the best of our knowledge, ethyl cellulose nanoparticles haven't been used before as delivery system for piroxicam. So, this delivery system might propose a new answer to an old question; how can we decrease gastric side effects of the non-steroidal anti-inflammatory drug, piroxiam?
Perspectives
Personally, I think the use of nanoparticles might be the answer to many unsolved questions in the field of drug delivery. However, promising as it might seem, it should go hand in hand with nano-toxicological studies. Also, pharmaceutical industry should participate in outlining the future of this field of research.
Dr. Salma Essam El-Habashy
Faculty of pharmacy, Alexandria university, Egypt
Read the Original
This page is a summary of: Ethyl cellulose nanoparticles as a platform to decrease ulcerogenic potential of piroxicam: formulation and in vitro/in vivo evaluation, International Journal of Nanomedicine, May 2016, Dove Medical Press,
DOI: 10.2147/ijn.s93354.
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