pH-sensitive liposomes for sorafenib and siRNA co-delivery

What is it about?

The present study aimed at the development of a pH-sensitive liposome to co-deliver drug and siRNA to tumor region. Driven by the electrostatic interaction, the pH-sensitive material, carboxymethyl chitosan (CMCS), was coated onto the surface of the cationic liposome (CL) pre-loaded with sorafenib (Sf) and siRNA (Si). In vitro and in vivo experiments were evaluated in HepG2 cells and the H22 cells-bearing Kunming mice model.

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Why is it important?

In current experimental conditions, this liposomal formulation did not show significant toxicity both in vitro and in vivo. Therefore, co-delivering Sf with siRNA by CMCS-SiSf-CL might provide a promising approach for tumor therapy.