What is it about?

In this study, a new method for detecting creatinine was developed. This novel sensor comprised of two ionic liquids, poly-lactic-co-glycolic acid (PLGA) and 1-butyl-3-methylimidazolium (BMIM) chloride, in the presence of 2',7'-dichlorofluorescein diacetate (DCFH-DA). PLGA and BMIM chloride formed a functional porous polymer structure (FPPS)-like structure.

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Why is it important?

The conversion of DCFH to DCF+ resulted in swelling of FPPS and increased solubility. This DCF+-based sensor could detect creatinine levels with detection limit of 5 µM and also measure the creatinine in blood. This novel method could be used in diagnostic applications for monitoring individuals with renal dysfunction.


In the near future, more focus on improving the sensor by increasing the fluorescence intensity should be carried out. This will allow the diabetes patient to use this sensor and check their creatinine level. This creatinine sensor can be especially useful for patients with renal disease or patients who have undergone kidney transplantations, as they can use it for home monitoring. This sensor is selective for creatinine only, and other biomolecules are not measured. With the help of nanoparticles, this method can be further improved by altering the morphology and size of the particles, external area of the pore, and adsorption properties and by increasing the transfer of electrons.

Dr. Sitansu Sekhar Nanda
Myongji University

Read the Original

This page is a summary of: Measurement of creatinine in human plasma using a functional porous polymer structure sensing motif, International Journal of Nanomedicine, August 2015, Dove Medical Press,
DOI: 10.2147/ijn.s88378.
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