What is it about?
The major drawback for cell penetrating peptide are its non specific nature which causes toxicity and off target effect.Carrier particles such as Nano particle or Liposomes are made specific by tagging cell surface specific marker.Hence in this work we have designed corneal and fungal speific cell penetrating peptides using the total proteome of the fungus and cornea.As a result of which we were able to get a peptide sequence which penetrates the epithelium of cornea and stays in stroma.Its also has a penetrating property in fungal species.Further to attain a sustained delivery of the peptide we have used gelatin hydrogel which is an FDA approved material.Hence the peptide has the potential to be used as an ocular drop.
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Why is it important?
Generally for designing specific carrier molecules,one specific protein will be targetted. In our work we used the published proteomics data of cornea and designed corneal specific peptide. We are the first to use gelatin hydrogel delivery system for CPP delivery.
Perspectives
Our paper provides an insight how the published proteomics data from the human subjects and proteomic database can be used for designing tissue specific peptides.This also open future avenues for designing therapeutic peptide with specific target.Hence our strategy can be used to minimise the off target effects for the peptides.
Dr Amit chatterjee
Sankara Nethralaya
Read the Original
This page is a summary of: Designing and enhancing the antifungal activity of corneal specific cell penetrating peptide using gelatin hydrogel delivery system, International Journal of Nanomedicine, January 2019, Dove Medical Press,
DOI: 10.2147/ijn.s184911.
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