What is it about?
Various studies have reported α-mangostin to exhibit antioxidant, antimicrobial, anti-inflamatory, and anticancer activities.18,19 However, the limited aqueous solubility, property constricts bioavailability of α-mangostin via oral route. Hence, an appropriate delivery system is absolutely required to improve the efficacy of α-mangostin.
Featured Image
Why is it important?
Nanotechnology seems to be a smart way to solve the clinical problem of α-mangostin.α-Mangostin can be incorporated into nano-sized biocompatible carriers such as biocompatible nanofibers. Decreasing particle size to nanoscale can greatly increase the surface area for a given quantity of biodegradable polymer material, which in turn significantly enhances the release of drug via drug diffusion and matrix degradation/erosion mechanisms.
Perspectives
Nanofibers as drug delivery systems with their very large surface area to volume ratios have the potential to improve drug release significantly. Furthermore, the small dimension of fibers combined with their microporous structure provided by the polymer mimics a protective shield, resulting in increased drug loading and drug stability
Dr. Ida Sriyanti
Universitas Sriwijaya
Read the Original
This page is a summary of: Mangosteen pericarp extract embedded in electrospun PVP nanofiber mats: physicochemical properties and release mechanism of α-mangostin, International Journal of Nanomedicine, August 2018, Dove Medical Press,
DOI: 10.2147/ijn.s167670.
You can read the full text:
Contributors
The following have contributed to this page
