What is it about?
Nanoparticles have enormous applications in textiles, cosmetics, electronics, and pharmaceuticals. But due to their exceptional physical and chemical properties, particularly as anti-microbial, anti-cancer, anti-bacterial, anti-inflammatory properties, nanoparticles have many potential applications in diagnosis as well as in treatment of various diseases. Over past few years nanoparticles have been extensively used to differentiate stem cells into neuronal cells, neuronal cell survivability, neuronal cell growth and expansion in both in vitro and in vivo conditions. The nanoparticles are known to produce both stimulatory and inhibitory effects on neurons cells, but there are few which can caused damaging effects on the neuronal cells. In this review, we discuss stimulatory, inhibitory, and damaging effects of the nanoparticle on the neuronal cells studied both in vitro and in vivo conditions.
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Why is it important?
The aim of this review is to summarize different effects of nanoparticles on the neuronal cells in both in vitro and in vivo conditions and give the reasons for the differential responses of various nanoparticles. Finally, this review provides a bird view approach on the effects of various nanoparticles on neuronal differentiation, neuronal survivability, neuronal growth, neuronal cell adhesion, and functional and behavioral recovery
Perspectives
The nanoparticles hold a great promise not only for neuronal differentiation but also for neuronal transplantation in various neurodegenerative diseases and for delivery of neuroprotective molecules in the body for both diagnostics and therapeutic applications. The success of nanoparticles in neural areas depends on the consistent data generation which depict less variability in both in vitro and in vivo models. The side effects or cytotoxic effects of nanoparticles also needs to be properly studied to lower the risk with proper dosages and correct treatment modalities. Finally, nanoparticles with highest efficacy and ability to repair the damage neurons with least side-effects in both in vitro and in vivo models hold great promise for the patients.
Prof. Firdos Alam Khan
Imam Abdulrahman Bin Faisal University
Read the Original
This page is a summary of: Impact of nanoparticles on neuron biology: current research trends, International Journal of Nanomedicine, May 2018, Dove Medical Press,
DOI: 10.2147/ijn.s165675.
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