What is it about?
Filed emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM) were used to characterize the nanoparticles properties. The anti-tumor activity of curcumin-loaded nanoparticles was assessed using MTT and real time PCR. FE-SEM and AFM data revealed the spherical morphology and the average size (<50 nm) of nanoparticles. In vitro cytotoxicity assay suggested that curcumin-loaded CS-ALG-STPP nanoparticles display significant anti-tumor activity compared to free curcumin. Gene expression level analysis showed that nanoparticles significantly increase apoptotic gene expression.
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Why is it important?
Natural herbal compounds have been widely introduced as the alternative therapeutic approaches in cancer therapy. Despite potent anti-cancer activity of curcumin, its clinical application has been limited because of low water solubility and resulting poor bioavailability. In this study, we designed a novel ultrasonic assisted method for synthesis of curcumin-loaded chitosan-alginate-sodium tripolyphosphate (CS-ALG-STPP) nanoparticles. Furthermore, the antitumor effects of curcumin-loaded nanoparticles have been evaluated in vitro.
Perspectives
This article also lead to rare disease groups contacting me and ultimately to a greater involvement in rare disease research.
maryam gholamitabar tabari
Infertility and reproductive Health research Center, Health research institute, Babol university of Medical science babol Iran
Read the Original
This page is a summary of: Induction of apoptosis in HeLa cancer cells by an ultrasonic-mediated synthesis of curcumin-loaded chitosan–alginate–STPP nanoparticles, International Journal of Nanomedicine, November 2017, Dove Medical Press,
DOI: 10.2147/ijn.s146516.
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