What is it about?
This study describes the development of drug-loaded nano porous scaffolds as a multi-functional coatings for endovascular stents in order to promote local and sustained release of rosuvastatin (Ros) and heparin (Hep) to injured artery walls after endovascular procedures via the electrospinning process.
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Why is it important?
Surface properties of endovascular stents play an important role in determining adhesion behaviors of endothelial cells and blood platelets. Owing to the complex mechanism of ISR, sole surface modification of endovascular devices are hard to completely prevent ISR or ST. However, combined with other techniques, such as drug delivery or cell seeding and related adjutant therapy, it could inhibit determining factors of ISR, including inflammation, proliferation of SMCs, thrombosis, and eventually prevent ISR.
Perspectives
These results imply that AC nano bers encapsulated with Ros and Hep drugs have great potential in the development of endovascular grafts with anti-thrombogenic properties that can accelerate the re-endothelialization, reduce the neointimal hyperplasia and in ammatory reaction, and improve the endothelial function.
Milka Janjic
Aristotle University of Thessaloniki
Read the Original
This page is a summary of: Surface modification of endovascular stents with rosuvastatin and heparin-loaded biodegradable nanofibers by electrospinning, International Journal of Nanomedicine, August 2017, Dove Medical Press,
DOI: 10.2147/ijn.s138261.
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