What is it about?
Here, we constructed a PAMAM dendrimer conjugate decorated by an integrin ligand Arg-Gly-Asp (RGD) peptide. RGD-PEG-PAMAM conjugates can activate the AKT/MAPK pathway in hepatic cells to promote cell proliferation and improve the basic function and ammonia metabolism.
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Why is it important?
RGD-PEG-PAMAM is conducive to the simulation of the growth environment of the hepatic cells in vivo and is more suitable for the transportation of nutrient than simple hepatic cell sphere aggregate culture. A larger number of cell spheres can be achieved in a short time, rapidly providing adequate functional hepatocytes for the biological artificial liver system.
Perspectives
A new nanostructured PAMAM dendrimer conjugate (RGD-PEG-PAMAM) decorated by an integrin ligand Arg-Gly-Asp (RGD) peptide was successfully constructed. RGD-PEG-PAMAM promotes hepatic cells to aggregate together in a sphere-like growth. Moreover, RGD-PEG-PAMAM improves the basic function and ammonia metabolism of hepatic cells. This study indicates that the hepatocytes sphere treated by RGD-PEG-PAMAM may be a choice for the source of liver cells in biological artificial liver system, its potential value need to be further investigated.
Nanhong Tang
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This page is a summary of: Arginine–glycine–aspartic acid–polyethylene glycol–polyamidoamine dendrimer conjugate improves liver-cell aggregation and function in 3-D spheroid culture, International Journal of Nanomedicine, August 2016, Dove Medical Press,
DOI: 10.2147/ijn.s113407.
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