Antisense nanocomplex treatment of Clostridium difficile

What is it about?

As an alternative to conventional antibiotic treatments, antisense antibiotics can allow the advantageous targeting of bacterial virulence functions essential for disease and recurrence. A major challenge toward the successful implementation of antisense treatments for bacterial infections is the development of efficient oligonucleotide delivery systems.

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Why is it important?

We report the first in vitro antisense treatment to inhibit the growth of the Gram-positive pathogen, C. difficile. We also describe the novel application of cationic acridinium bolasomes as nanocarriers for antisense oligonucleotides for a bacterium, with potential application to other species.