What is it about?
Carbapenems are considered as one of the last resorts for treating multidrug-resistant Gram-negative bacilli, including ESBL-producing Enterobacteriaceae. In our epidemiological survey, we observed an increased frequency of infection with OXA-48 carbapenemase -producing E. coli and K. pneumoniae isolates. In addition, our report describes the first identification of the epidemic multidrug-resistant lineage K. pneumoniae ST147, co-producing ESBL and the blaOXA-48 gene from a hospital setting in Algeria. Also, this study represents the second report of the internationally successful lineage K. pneumoniae ST101-producing OXA-48 in Algeria. Interestingly, these epidemic strains carrying blaOXA-48 beta-lactamase have been involved in several outbreaks in North African countries and also in some European regions. On the other hand, this paper describes the first detection of OXA-48-producing E. coli ST533 and K. pneumoniae ST163 and ST2017
Featured Image
Why is it important?
The emergence of carbapenemase-producing strains in the community represents a major epidemiological and therapeutic problem, our document represents the first report describing E. coli and K. pneumoniae isolates harboring the blaOXA-48 carbapenemase gene from the community in Algeria. Given that the outpatients included in our investigation had not previously used antibiotics, this suggests that resistance could be acquired via contact with animals or transmitted to humans through the food chain. On the other hand, to our knowledge, imipenem-resistant P. aeruginosa producing ESBL characterized in this study have never been detected in Algeria. Moreover, these isolates were assigned to the successful international clone ST654, usually associated with a multidrug-resistant phenotype.
Perspectives
In this study we investigated the occurrence of carbapenem-resistant Gram-negative bacilli isolated from inpatients and outpatients at an Algerian hospital in Annaba city in North East Algeria, and we screened their resistance mechanisms and genetic relatedness. Nevertheless, to better inspect the spread of carbapenem resistant Gram-negative bacilli in this country, it is necessary to expand the number of the strains and locations in any future epidemiological studies. On the other hand, this article describes for the first time the emergence of OXA-48-producing E. coli and K. pneumoniae in the community, leading to major problems for managing microbial infections. Therefore, we highlight the need to establish monitoring systems in order to prevent a much wider dissemination of carbapenemase producers in Algeria
Microbiologist Nadjette BOURAFA
Read the Original
This page is a summary of: Molecular characterization of carbapenem-resistant Gram-negative bacilli clinical isolates in Algeria, Infection and Drug Resistance, May 2018, Dove Medical Press,
DOI: 10.2147/idr.s150005.
You can read the full text:
Contributors
The following have contributed to this page
