What is it about?
In the present study, an attempt was made to study the brain bioavailability of commonly used anti-Alzheimer drug donepezil liposomal formulation by intranasal route in rats.
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Why is it important?
The adequate amount of drug delivery to the brain in neurological patients is a major problem. The cells of the blood-brain barrier display few essential qualities, such as the presence of tight and compact junction, lack of aperture, and a reduced pinocytic behavior. These particular types of cells help to limit the passage of the active molecules from the vascular to the extracellular area of the brain. Intranasal administration of donepezil liposomes significantly increased the brain bioavailability of the drug as compared with conventional dosage form and route of administration.
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This page is a summary of: Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil, Drug Design Development and Therapy, January 2016, Dove Medical Press,
DOI: 10.2147/dddt.s93937.
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