What is it about?
Stabilization of peptides and proteins in a designated delivery system against degradation, particularly in the gastrointestinal tract (GIT), is a prerequisite for oral delivery. This can be carried out by using several excipients such as salts, amino acids, surfactants, polyhydric alcohols, and carbohydrates. The latter include glucosamine and chitosans. Chitosans are non-toxic, degradable, and biocompatible polymers that exhibit different characteristics. This allows them to be used as excipients for protein formulations intended for in vivo delivery of biopharmaceuticals.
Featured Image
Why is it important?
Our findings offer an opportunity to incorporate glucosamine in oral insulin delivery systems in order to enhance a reduction in blood glucose levels.
Perspectives
This research field is challenging. Wishing to have a universal patented oral delivery system for peptides and proteins.
Dr Mahmoud M.H. Al Omari
The Jordanian Pharmaceutical Manufacturing
Read the Original
This page is a summary of: Influence of glucosamine on the bioactivity of insulin delivered subcutaneously and in an oral nanodelivery system, Drug Design Development and Therapy, November 2015, Dove Medical Press,
DOI: 10.2147/dddt.s91974.
You can read the full text:
Contributors
The following have contributed to this page
