Mushroom tyrosinase inhibitors

What is it about?

Increasing the activity of the tyrosinase causes excessive production of melanin and, as a result, causes hyperpigmentation problems such as melasma, skin spots and so on may occur. Therefore, the discovery and synthesis of safe and effective inhibitors for treating and preventing skin disorders are very important in the field of the medicinal and cosmetic industry

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Why is it important?

In this study, for the first time, we synthesized a series of novel azo-pyrimidine dyes and evaluated the inhibitory activities of these low-cost and easy-to-prepare compounds against mushroom tyrosinase based on dopaquinone production. Our findings suggest that pyrimidine derivatives can be considered as safe and efficient tyrosinase inhibitors.