What is it about?
In this review, we discuss the current data about the anatomy and function of bone tissue with particular regard to influence of prostaglandins. Bone tissue dynamics are characterized by a constant remodeling process that involves all bone tissue cells. Remodeling is also a vital element of healing processes and in adapting bone tissue to stress responses. The activity of prostaglandins in bone tissue is defined by maintaining bone remodeling balance and its reactions to humoral mediators and mechanical stress.
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Why is it important?
In this manuscript the authors focused on the influence of prostaglandins on the osteogenic cells and physiology of bone tissue in order to emphasize the negative effects of their blockade by NSAIDs.
Perspectives
The role of NSAIDs on presented cells of bone tissue and all stages of bone healing will be discussed in the manuscript about the effects of non-steroidal anti-inflammatory drugs on bone repair. I hope that our publication help improving the knowledge about bone healing in connection with NSAIDs therapy.
Barbara Lisowska
Read the Original
This page is a summary of: Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism, Drug Design Development and Therapy, June 2018, Dove Medical Press,
DOI: 10.2147/dddt.s164562.
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