What is it about?
GKN1 is a stomach specific protein. Gene for gastrokine 1 (GKN1) was identified as one of the most significant in gastric cancer and indicated as a potential therapeutic target.
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Why is it important?
The evaluation of GKN1 expression seems to be a useful indicator of the presence of neoplastic or inflammatory lesions in the gastric mucosa. GKN1 expression is decreased in gastric tumor tissues and derived cell lines and its up-regulation in cell lines of gastric cancer induces cells apoptosis.
Perspectives
The aspect of quantitative serum GKN1 evaluation is new in the context of available literature and requires further studies.
Dr. Olga Martyna Koper-Lenkiewicz
Medical University of Białystok, Department of Clinical Laboratory Diagnostics
Read the Original
This page is a summary of: The role and diagnostic potential of gastrokine 1 in gastric cancer, Cancer Management and Research, March 2019, Dove Medical Press,
DOI: 10.2147/cmar.s194949.
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