What is it about?
Phosphatase of regenerating liver-3 (PRL-3) has been shown to be highly expressed in various types of cancers and is related to poor prognosis. Our previous study showed that silencing of PRL-3 leads to increased reactive oxygen species (ROS). However, the mechanism of PRL-3 regulating ROS is not clear. Our study presents the first evidence that PRL-3 is involved in the regulation of mitochondria superoxide anion as a transcriptional factor.
Featured Image
Why is it important?
Our study presents the first evidence that PRL-3 is involved in the regulation of mitochondria superoxide anion as a transcriptional factor.
Perspectives
Our study presents the first evidence that PRL-3 is involved in the regulation of mitochondria superoxide anion as a transcriptional factor.
Dr. YONGYONG YANG
Northwestern University
Read the Original
This page is a summary of: Knockdown of PRL-3 increases mitochondrial superoxide anion production through transcriptional regulation of RAP1, Cancer Management and Research, October 2018, Dove Medical Press,
DOI: 10.2147/cmar.s165344.
You can read the full text:
Contributors
The following have contributed to this page
