What is it about?
This article is about Alzheimer’s disease (AD) which is a progressive, neurodegenerative disease and the most common form of dementia in elderly people. It is an emerging public health problem that poses a huge societal burden. The economic burden of AD can be explained by fact that Health care costs of dementia in 2015 surpassed $818 billion (USD), and this figure is estimated to be as high as $2 trillion by 2030.1.
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Why is it important?
Current drugs help mask the symptoms of Alzheimer's, but do not treat the underlying disease or delay its progression, so we can say that Currently, there is no cure for Alzheimer's.........
Perspectives
Future research should be focused on identifying low effect size and rare variants that may explain missing heritability. In future, deep resequencing can be used for an effective and accurate approach to identify novel rare variants associated with AD, which might provide further insights into the underlying mechanisms of disease. It is evident that epistatic interaction is involved in complex diseases such as AD, and this should not be ignored. Furthermore, novel risk genes for AD can be identified by gene profiling.
Dr MOHAN GIRI
Chongqing Medical University
Read the Original
This page is a summary of: Genes associated with Alzheimer's disease: an overview and current status, Clinical Interventions in Aging, May 2016, Dove Medical Press,
DOI: 10.2147/cia.s105769.
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