Sphingosine 1-phosphate signalling in Head and Neck cancer
What is it about?
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid involved in inflammation, tumor progression, and angiogenesis. Its been found that HNSCC often develops resistance to chemotherapy and targeted drug therapy. Thus, to overcome the problem of drug resistance, there is a need to explore novel drug targets. Therefore we are focusing on S1P signalling metabolizing enzymes.
Why is it important?
In this article, we had mentioned that SphK1 regulates tumor progression, invasion, metastasis, and chemoresistance in HNSCC. SphK1 expression is highly elevated in advanced stage HNSCC tumors and correlates with poor survival. In this article, we review current knowledge regarding the role of S1P receptors and enzymes of S1P metabolism in HNSCC carcinogenesis. Furthermore, we summarize the current perspectives on therapeutic approaches for targeting S1P pathway for treating HNSCC
The following have contributed to this page: Dr Ashok Kumar, Dr Rajeev Nema, and Ms. Supriya Vishwakarma