What is it about?
We explore the new approaches to treat cancer by means of small interfering RNAs. These small molecules are designed to inhibit the synthesis of special proteins, that help cancer cell to escape from apoptosis.
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Why is it important?
Most anticancer drugs are administrated in the sufficient dozes to kill the cancer, but toxic to the full organism. In addition in 40-60% cases drug resistance is developed. We have identified that expression of two genes: Livin and Birc3 are critical to cancer sensitivity to the drug. Double inhibition of their synthesis in 7-fold enhances cancer cell sensitivity to small dozes of the drug. This is a good aproach to improve anticancer treatment in future.
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This page is a summary of: Double siRNA-targeting of cIAP2 and LIVIN results in synergetic sensitization of HCT-116 cells to oxaliplatin treatment, OncoTargets and Therapy, September 2013, Taylor & Francis,
DOI: 10.2147/ott.s44893.
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