What is it about?

Circular RNAs (circRNAs) are a newly discovered class of endogenous non-coding RNAs. Because of their high stability and abundance, tissue-specific expression, and easy detection, circRNAs are considered ideal biomarkers for cancer diagnosis and prognosis. In this review, we summarize the current literature regarding human circRNAs related to colorectal cancer (CRC) and present an overview of the potential clinical implications of circRNAs with respect to CRC.

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Why is it important?

CRC is the third most common cancer and the second leading cause of cancer-related death globally. Thus, understanding the molecular mechanisms involved in the development and progression of CRC is vital.

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This page is a summary of: Emerging roles of circular RNAs in colorectal cancer, OncoTargets and Therapy, June 2019, Dove Medical Press, DOI: 10.2147/ott.s208235.
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